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HelpTest Code ALDNA Aldosterone with Sodium, 24 Hour, Urine
Reporting Name
Aldosterone with Sodium, UrineUseful For
Investigating primary aldosteronism (eg, adrenal adenoma/carcinoma and adrenal cortical hyperplasia) and secondary aldosteronism (eg, renovascular disease, salt depletion, potassium loading, cardiac failure with ascites, pregnancy, Bartter syndrome) in conjunction with urine sodium levels
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| ALDU | Aldosterone, U | Yes | Yes |
| NAU | Sodium, 24 HR, U | Yes | Yes |
Method Name
ALDU: Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
NAU: Potentiometric, Indirect Ion-Selective Electrode (ISE)
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
UrineNecessary Information
24-Hour volume (in milliliters) is required.
Specimen Required
Patient Preparation: Spironolactone (Aldactone) should be discontinued for 4 to 6 weeks before testing. The plasma renin activity cannot be interpreted if the patient is being treated with spironolactone.
Supplies: Sarstedt Aliquot Tube 5mL (T914)
Container/Tube: 2 Plastic, 5-mL tubes
Specimen Volume: 10 mL
Collection Instructions:
1. Add 25 mL of 50% acetic acid as preservative at start of collection. Use 15 mL of 50% acetic acid for children under the age of 5 years. This preservative is intended to achieve a pH of between approximately 2 and 4.
2. Collect urine for a full 24 hours (required) and record the total volume.
3. Place 5 mL of well mixed, 24-hour urine in plastic, 5-mL tube and label as Aldosterone.
4. Place 5 mL of well mixed, 24-hour urine in plastic, 5-mL tube and label as Sodium.
Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens for multiple collections.
An entire 24-hour urine collection is also acceptable.
Additional Information:
1. Starting and ending times of collection are required.
2. Follow instructions in Urine Collection in Specimen Collection and Preparation in General Information.
Specimen Minimum Volume
2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Refrigerated (preferred) | 14 days | |
| Frozen | 14 days | ||
| Ambient | 7 days |
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Special Instructions
Reference Values
ALDOSTERONE
0-30 days: 0.7-11.0 mcg/24 h*
1-11 months: 0.7-22.0 mcg/24 h*
≥1 year: 2.0-20.0 mcg/24 h
*Loeuille GA, Racadot A, Vasseur P, Vandewalle B. Blood and urinary aldosterone levels in normal neonates, infants and children. Pediatrie 1981;36(5):335-344
SODIUM
41-227 mmol/24 h
If the 24-hour urinary sodium excretion is greater than 200 mmol, the urinary aldosterone excretion should be less than10 mcg.
Day(s) Performed
Tuesday, Thursday
CPT Code Information
82088-Aldosterone
84300-Sodium
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| ALDNA | Aldosterone with Sodium, Urine | 94871-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| NA_24 | Sodium, 24 HR, U | 2956-1 |
| 8556 | Aldosterone, U | 1765-7 |
| TM47 | Collection Duration (h) | 13362-9 |
| TM11 | Collection Duration | 13362-9 |
| VL9 | Urine Volume | 3167-4 |
| VL45 | Volume (mL) | 3167-4 |